Guttiferone BL with antibacterial activity from the fruits of Allanblackia gabonensis

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Nganou B. K., Konga I. S., Fankam A. G., Bitchagno G. T. M., Sonfack G., Nayim P., ...Daha Fazla

NATURAL PRODUCT RESEARCH, cilt.33, sa.18, ss.2638-2646, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 18
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/14786419.2018.1465424
  • Dergi Adı: NATURAL PRODUCT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2638-2646
  • Anahtar Kelimeler: Allanblackia gabonensis, antibacterial activity, Clusiaceae, guttiferone BL, INHIBITORY NATURAL-PRODUCTS, STEM BARK, BENZOPHENONE DERIVATIVES, ANTIPLASMODIAL ACTIVITY, PRENYLATED XANTHONE, MONTICOLA, CONSTITUENTS, EXTRACT
  • Anadolu Üniversitesi Adresli: Evet

Özet

Allanblackia genus, an endless source of bioactive compounds, was investigated for its antibacterial properties. The chemical study of the methanol extract from the fruits of Allanblackia gabonensis resulted in the isolation of the undescribed guttiferone BL (1) along with the known kaempferol (2), morelloflavone (3), morelloflavone 7 ''-O-beta-D-glucopyranoside (4), beta-sitosterol 3-O-beta-D-glucopyranoside and beta-sitosterol. Their structures were determined using spectrometry and spectroscopic techniques. The antibacterial activity was evaluated against five Gram-negative and two Gram-positive strains using a broth micro-dilution method. Compounds displayed low to significant activity against the tested bacterial strains with MICs ranging from 8 to 512 mu g/mL. Morelloflavone (3) presented significant activity against E. coli ATCC8739 (MIC = 8 mu g/mL) while guttiferone BL (1) exhibited low activity (MICs = 256-512 mu g/mL) against all the tested strains. The crude extract also had moderate to significant activity against the tested bacterial strains.