Phenolic compounds of Sideritis ozturkii and their in vivo anti-inflammatory and antinociceptive activities

Küpeli E., Şahin F. P., Çaliş I., Yeşilada E., Ezer N.

Journal of Ethnopharmacology, vol.112, no.2, pp.356-360, 2007 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 112 Issue: 2
  • Publication Date: 2007
  • Doi Number: 10.1016/j.jep.2007.03.017
  • Journal Name: Journal of Ethnopharmacology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.356-360
  • Keywords: Acylated flavone glycosides, Anti-inflammatory activity, Antinociceptive activity, Flavonoids, Lamiaceae, Sideritis ozturkii
  • Anadolu University Affiliated: No

Abstract

Acetone extract from aerial parts of Sideritis ozturkii Aytaç & Aksoy and its fractions were investigated for its in vivo anti-inflammatory and antinociceptive activities. For the anti-inflammatory activity assessment, carrageenan-induced hind paw edema and for the antinociceptive activity, p-benzoquinone-induced abdominal constriction tests were used. Acetone extract of the plant and its phenolic fraction were found to possess significant inhibitory activity on these in vivo models in mice. Ozturkoside A (chrysoeriol 7-O-[2′′′-O-caffeoyl-6′′′-O-acetyl-β-d-glucopyranosyl-(1 → 2)-β-d-glucopyranoside]); ozturkoside B (chrysoeriol 7-O-[2′′′-O-caffeoyl-β-d-glucopyranosyl-(1 → 2)-β-d-glucopyranoside]); and ozturkoside C (chrysoeriol 7-O-[2′′′-O-p-coumaroyl-6′′′-O-acetyl-β-d-glucopyranosyl-(1 → 2)-β-d-glucopyranoside]) were isolated from the active phenolic fraction. The structures of isolated compounds were elucidated by spectroscopic techniques (UV, IR, 1D- and 2D-NMR, MS). Ozturkoside C showed notable antinociceptive and anti-inflammatory activities without inducing any apparent acute toxicity or gastric damage. Although the activity of ozturkosides A and B were found insignificant in statistical analysis, some inhibitory effect was observed. Accordingly, it is suggested that these components in phenolic fraction might possibly share the antinociceptive and anti-inflammatory activities together. © 2007.