Synthesis and In Vitro Evaluation of Furan-Based Chalcone Derivatives as Antimicrobial Agents

ÖZDEMİR A., ALTINTOP M. D., CANTÜRK Z., KAPLANCIKLI Z. A.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.12, sa.7, ss.607-611, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 7
  • Basım Tarihi: 2015
  • Doi Numarası: 10.2174/1570180812999150202112352
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.607-611
  • Anahtar Kelimeler: Chalcone, furan, antibacterial activity, anticandidal activity, ANTIBACTERIAL ACTIVITY, STAPHYLOCOCCUS-AUREUS, BIOLOGICAL EVALUATION, PRENYLATED CHALCONES, CYTOTOXICITY, INHIBITION, MECHANISM, REDUCTASE, BEARING
  • Anadolu Üniversitesi Adresli: Evet

Özet

Some furan-based chalcone derivatives were synthesized via the Claisen-Schmidt condensation of 5-arylfurfural derivatives with 4'-cyanoacetophenone. The synthesized derivatives were investigated for their antimicrobial activity using a broth microdilution assay. Among these compounds, 1-(4-cyanophenyl)-3-[5-(4-nitrophenyl)-2-furyl]-2-propen-1-one (4) can be considered as the most promising antimicrobial agent against Enterococcus faecalis (ATCC 51922) and Candida albicans. Compound 4 showed antimicrobial activity against E. faecalis with a MIC value of 100 mu g/mL, whereas chloramphenicol exhibited its antibacterial activity with a MIC value of 200 mu g/mL. Compound 4 (MIC = 100 mu g/mL) was also more effective than ketoconazole (MIC = 200 mu g/mL) against C. albicans. Microbiological assay pointed out the importance of p-nitro substituent for antimicrobial activity.