Synthesis and analgesic activity of some triazoles and triazolothiadiazines

Turan-Zitouni G., KAPLANCIKLI Z. A., Erol K., KILIÇ F. S.

FARMACO, vol.54, no.4, pp.218-223, 1999 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 4
  • Publication Date: 1999
  • Doi Number: 10.1016/s0014-827x(99)00016-6
  • Journal Name: FARMACO
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.218-223
  • Keywords: tetrahydronaphthalentriazoles, triazaolothiadiazines, analgesic activity, ANTIFUNGAL ACTIVITY
  • Anadolu University Affiliated: Yes

Abstract

The synthesis of some triazoles and triazolothiadiazines starting from (5,6,7,8-tetrahydronaphthalen-2-yl)oxyacetic acid is described. The chemical structure of the compounds were elucidated by analytical, IR, H-1 NMR and mass spectral studies. Some of the newly synthesized compounds were tested for analgesic activity and compounds 5b, 5c, and 5d exhibited promising analgesic activity. (C) 1999 Elsevier Science S.A. All rights reserved.