In silico Molecular Docking and ADME Studies of 1 3,4-Thiadiazole Derivatives in Relation to in vitro PON1 Activity

SEVER B., KÜÇÜKOĞLU K., NADAROĞLU H., ALTINTOP M. D.

CURRENT COMPUTER-AIDED DRUG DESIGN, vol.15, no.2, pp.136-144, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.2174/1573409914666180518085908
  • Journal Name: CURRENT COMPUTER-AIDED DRUG DESIGN
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.136-144
  • Keywords: Paraoxonase 1, thiadiazole, molecular docking, ADME, antioxidant activity, PON1 activators, HUMAN SERUM PARAOXONASE, PURIFICATION, BINDING, 1,3,4-THIADIAZOLES, INHIBITION, SOLUBILITY, PROTEINS, DESIGN
  • Anadolu University Affiliated: Yes

Abstract

Background: Paraoxonase 1 (PON1) is a paraoxonase, arylesterase and lactonase associated with protection of lipoproteins and cell membranes against oxidative modification.