In silico Molecular Docking and ADME Studies of 1 3,4-Thiadiazole Derivatives in Relation to in vitro PON1 Activity

SEVER, BELGİN; KÜÇÜKOĞLU, KAAN; NADAROĞLU, Hayrunnisa; ALTINTOP, MEHLİKA

doi:10.2174/1573409914666180518085908

In silico Molecular Docking and ADME Studies of 1 3,4-Thiadiazole Derivatives in Relation to in vitro PON1 Activity

SEVER B., KÜÇÜKOĞLU K., NADAROĞLU H., ALTINTOP M. D.

CURRENT COMPUTER-AIDED DRUG DESIGN, cilt.15, sa.2, ss.136-144, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 15 Sayı: 2
Basım Tarihi: 2019
Doi Numarası: 10.2174/1573409914666180518085908
Dergi Adı: CURRENT COMPUTER-AIDED DRUG DESIGN
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.136-144
Anahtar Kelimeler: Paraoxonase 1, thiadiazole, molecular docking, ADME, antioxidant activity, PON1 activators, HUMAN SERUM PARAOXONASE, PURIFICATION, BINDING, 1,3,4-THIADIAZOLES, INHIBITION, SOLUBILITY, PROTEINS, DESIGN
Anadolu Üniversitesi Adresli: Evet

Özet

Background: Paraoxonase 1 (PON1) is a paraoxonase, arylesterase and lactonase associated with protection of lipoproteins and cell membranes against oxidative modification.