Synthesis and cytotoxic activities of transition-metal complexes of a binaphthyl-linked bipyridine ligand

Beynek N., ULUÇAM G., BENKLİ K.

Transition Metal Chemistry, cilt.34, sa.3, ss.289-292, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 3
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s11243-009-9192-1
  • Dergi Adı: Transition Metal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.289-292
  • Anadolu Üniversitesi Adresli: Evet

Özet

A binaphthyl-linked bipyridyl compound, 1,1?-bis(6-methyl-6?-oxymethylenyl- 2,2?-bipyridine)binaphthyl, (L) has been synthesised and used as a ligand for the formation of Cu(II), Ni(II), and Co(II) complexes. The ligand and its transition-metal complexes were characterized by physico-chemical and spectroscopic methods. The complexes were also investigated for cytotoxic activity. The cytotoxicity of complexes, CuL(ClO4)2, NiL(ClO4)2(H2O), CoL(ClO4) 2, were tested in vitro applying seven well-characterized human tumor cell lines, MCF7, EVSA-T, WIDR, IGROV, M19 MEL, A498, H226, and the microculture sulforhodamine B (SRB) test. All complexes show a very high cytotoxicity (ID50 < 250 ng/ml) in these cell lines. © 2009 Springer Science+Business Media B.V.