A microscopic study of kidney tissue in familial mediterranean fever patients

SARI KILIÇASLAN S. M., Ayvali C., Taştan H.

Cell Biochemistry and Function, vol.25, no.4, pp.363-367, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1002/cbf.1286
  • Journal Name: Cell Biochemistry and Function
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.363-367
  • Keywords: Familial Mediterranean Fever, Kidney, Transmission electron microscopy
  • Anadolu University Affiliated: Yes


Familial Mediterranean Fever (FMF) is an autosomal recessive hereditary disease leading mostly to renal failure and nephrotic syndrome. The ultrastructure of kidney has not been fully investigated in FMF associated renal disease. The aim of this study is to provide further evidence on the ultrastructure of kidney in patients with FMF who suffer from renal disease. Renal biopsies obtained from two patients who were diagnosed with FMF renal disease complications were examined. Examination of renal tissue by light and electron microscopy identified degenerations both in tubules and the filtration barrier. Foot processes were partly effaced. Amorphous material was found in thickened glomerular basement membranes. Fibrous material deposits in thick Bowman's capsule wall were also seen. Finally, degeneration in the form of folding of plasma membrane and vacuolization as well as fusion in mitochondria cristae, was observed. Accumulation of tissue remnants in the lumen was also found in tubules. Copyright © 2005 John Wiley & Sons, Ltd.