Copy For Citation
ATLI EKLİOĞLU Ö., ILGIN S., ERGUN B., BURUKOĞLU DÖNMEZ D., MUSMUL A., SIRMAGÜL B.
ANATOLIAN JOURNAL OF CARDIOLOGY, vol.17, no.1, pp.8-17, 2017 (SCI-Expanded)
-
Publication Type:
Article / Article
-
Volume:
17
Issue:
1
-
Publication Date:
2017
-
Doi Number:
10.14744/anatoljcardiol.2016.6891
-
Journal Name:
ANATOLIAN JOURNAL OF CARDIOLOGY
-
Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
-
Page Numbers:
pp.8-17
-
Keywords:
Pulmonary hypertension, vascular remodeling, monocrotaline, everolimus, alagebrium, matrix metalloproteinases, ARTERIAL-HYPERTENSION, EXTRACELLULAR-MATRIX, HEART, EXPRESSION, INFLAMMATION, INHIBITORS, MODEL
-
Anadolu University Affiliated:
Yes
Abstract
Objective: In our study, sildenafil alone and everolimus or alagebrium in combination with sildenafil were investigated in terms of their additional therapeutic and anti-remodeling activity in monocrotaline-induced pulmonary hypertension (PH) model in rats. In particular, the inter-relationships between PH and matrix metalloproteinases (MMPs) were investigated.