Matrix metalloproteinases are possible targets in monocrotaline-induced pulmonary hypertension: investigation of anti-remodeling effects of alagebrium and everolimus

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ATLI EKLİOĞLU Ö., ILGIN S., ERGUN B., BURUKOĞLU DÖNMEZ D., MUSMUL A., SIRMAGÜL B.

ANATOLIAN JOURNAL OF CARDIOLOGY, vol.17, no.1, pp.8-17, 2017 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 17 Issue: 1
• Publication Date: 2017
• Doi Number: 10.14744/anatoljcardiol.2016.6891
• Journal Name: ANATOLIAN JOURNAL OF CARDIOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.8-17
• Keywords: Pulmonary hypertension, vascular remodeling, monocrotaline, everolimus, alagebrium, matrix metalloproteinases, ARTERIAL-HYPERTENSION, EXTRACELLULAR-MATRIX, HEART, EXPRESSION, INFLAMMATION, INHIBITORS, MODEL
• Anadolu University Affiliated: Yes

Abstract

Objective: In our study, sildenafil alone and everolimus or alagebrium in combination with sildenafil were investigated in terms of their additional therapeutic and anti-remodeling activity in monocrotaline-induced pulmonary hypertension (PH) model in rats. In particular, the inter-relationships between PH and matrix metalloproteinases (MMPs) were investigated.