Ocular application of chitosan

BAŞARAN E., Yazan Y.

EXPERT OPINION ON DRUG DELIVERY, vol.9, no.6, pp.701-712, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 9 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.1517/17425247.2012.681775
  • Journal Name: EXPERT OPINION ON DRUG DELIVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.701-712
  • Keywords: bioavailability, chitosan, ocular drug delivery, safety of chitosan, DRUG-DELIVERY SYSTEM, NANOSTRUCTURED LIPID CARRIERS, IN-VITRO RELEASE, CYCLOSPORINE-A, BIOMEDICAL APPLICATIONS, PRECORNEAL RETENTION, POTENTIAL APPROACH, EUDRAGIT RS100(R), TOPICAL USE, NANOPARTICLES
  • Anadolu University Affiliated: Yes

Abstract

Introduction: A major problem in ocular therapeutics with classical formulations is the maintenance of an effective drug concentration at the site of action for a long period of time. Enhancement of ocular bioavailability with increased dose penetration and longer retention time at desired sites can be achieved by recent formulations. Chitosan stands out with its unique structural advantageous characteristics for different types of formulations like in situ gelling systems, micro- and nanoparticles, inserts, etc.