Ocular application of chitosan

BAŞARAN E., Yazan Y.

EXPERT OPINION ON DRUG DELIVERY, cilt.9, sa.6, ss.701-712, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 9 Sayı: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1517/17425247.2012.681775
  • Dergi Adı: EXPERT OPINION ON DRUG DELIVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.701-712
  • Anahtar Kelimeler: bioavailability, chitosan, ocular drug delivery, safety of chitosan, DRUG-DELIVERY SYSTEM, NANOSTRUCTURED LIPID CARRIERS, IN-VITRO RELEASE, CYCLOSPORINE-A, BIOMEDICAL APPLICATIONS, PRECORNEAL RETENTION, POTENTIAL APPROACH, EUDRAGIT RS100(R), TOPICAL USE, NANOPARTICLES
  • Anadolu Üniversitesi Adresli: Evet

Özet

Introduction: A major problem in ocular therapeutics with classical formulations is the maintenance of an effective drug concentration at the site of action for a long period of time. Enhancement of ocular bioavailability with increased dose penetration and longer retention time at desired sites can be achieved by recent formulations. Chitosan stands out with its unique structural advantageous characteristics for different types of formulations like in situ gelling systems, micro- and nanoparticles, inserts, etc.