The determination of levofloxacin by flow injection analysis using UV detection, potentiometry, and conductometry in pharmaceutical preparations
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol.30, no.3, pp.881-885, 2002 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 30 Issue: 3
- Publication Date: 2002
- Doi Number: 10.1016/s0731-7085(02)00354-0
- Journal Name: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.881-885
- Keywords: levofloxacin, flow injection analysis, potentiometry, conductometry, spectrophotometry, pharmaceutical applications, HUMAN URINE, HPLC ASSAY, SERUM, TABLETS
- Anadolu University Affiliated: Yes
Abstract
A flow injection analysis (FIA) using UV detection, potentiometry and conductometry for levofloxacin (LVF) are described in this study. The best solvent system was found to consist of 0.2 V acetate buffer at pH 3 having 10% MeOH. A flow rate of 1 ml min(-1) was pumped and active material was detected at 288 nm. The detection limit (LOD) and limit of quantification (LOQ) for FIA were calculated to be 3 x 10(-7) M (S/N = 3) and 1 x 10(-7) M (S/N = 10), respectively. In the analysis of tablets, the RSD values were found to be 0.83, 0.98 and 0.99 for FIA, potentiometric and conductometric methods, respectively. (C) 2002 Elsevier Science B.V. All rights reserved.