Synthesis, Antibacterial and Antifungal Activities of Some Carbazole Dithiocarbamate Derivatives

Karaburun A. Ç., Kaplancıklı Z. A., Gündoğdu-Karaburun N., Demirci F.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.8, sa.9, ss.811-815, 2011 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 9
  • Basım Tarihi: 2011
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.811-815
  • Anahtar Kelimeler: Antibacterial activity, Antifungal activity, Carbazole, Dithiocarbamate, ACID-ESTERS
  • Anadolu Üniversitesi Adresli: Evet

Özet

In this study, we aimed at the synthesis of new N, N-disubstituted dithiocarbamoic acid, 2-[(9-ethyl-9H-carbazol-3-yl) amino]-2-oxoethyl esters and their antimicrobial evaluations. The chemical structures of the compounds were elucidated by IR, 1 H NMR, C-13 NMR, MS spectral data and elemental analysis. The antibacterial and antifungal activities of the synthesised derivatives were tested against Gram (+), Gram (-) bacteria and yeasts such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhimurium, Bacillus cereus, Methicillin-resistant Staphylococcus aureus (MRSA), Candida albicans (two strains), Candida glabrata, Candida tropicalis, Candida parapsilosis and Saccharomyces cerevisiae using a microbroth dilution technique. The results showed that the compounds displayed different degrees of antimicrobial activities; however, when compared almost all of the compounds displayed better antifungal activities (minimum inhibitory concentrations, 312.5->1250 mu g mL(-1)).