Synthesis, Antibacterial and Antifungal Activities of Some Carbazole Dithiocarbamate Derivatives
LETTERS IN DRUG DESIGN & DISCOVERY, vol.8, no.9, pp.811-815, 2011 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 8 Issue: 9
- Publication Date: 2011
- Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.811-815
- Keywords: Antibacterial activity, Antifungal activity, Carbazole, Dithiocarbamate, ACID-ESTERS
- Anadolu University Affiliated: Yes
Abstract
In this study, we aimed at the synthesis of new N, N-disubstituted dithiocarbamoic acid, 2-[(9-ethyl-9H-carbazol-3-yl) amino]-2-oxoethyl esters and their antimicrobial evaluations. The chemical structures of the compounds were elucidated by IR, 1 H NMR, C-13 NMR, MS spectral data and elemental analysis. The antibacterial and antifungal activities of the synthesised derivatives were tested against Gram (+), Gram (-) bacteria and yeasts such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhimurium, Bacillus cereus, Methicillin-resistant Staphylococcus aureus (MRSA), Candida albicans (two strains), Candida glabrata, Candida tropicalis, Candida parapsilosis and Saccharomyces cerevisiae using a microbroth dilution technique. The results showed that the compounds displayed different degrees of antimicrobial activities; however, when compared almost all of the compounds displayed better antifungal activities (minimum inhibitory concentrations, 312.5->1250 mu g mL(-1)).