The interactions of cephalosporins on polyol pathway enzymes from sheep kidney

ŞENGÜL B., BEYDEMİR Ş.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, vol.124, no.1, pp.35-44, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 124 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1080/13813455.2017.1358749
  • Journal Name: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.35-44
  • Keywords: Aldose reductase, sorbitol dehydrogenase, cephalosporins, inhibition, diabetes, REDUCTASE INHIBITORY-ACTIVITY, ALDOSE REDUCTASE, CARBONIC-ANHYDRASE, IN-VITRO, KINETIC-PROPERTIES, ANTIBIOTIC DRUG, SORBITOL, GLUCOSE-6-PHOSPHATE-DEHYDROGENASE, ERYTHROCYTES, PURIFICATION
  • Anadolu University Affiliated: Yes

Abstract

Context: Cephalosporins are derived from the fungus Acremonium. Due to their strong bactericidal ability, these drugs have to a wide usage in medicine.Objective: An investigation of the effects on sheep renal aldose reductase (AR) and sorbitol dehydrogenase (SDH) of cefoperazone, cefazolin, cefuroxime, ceftazidime and ceftriaxone as cephalosporin drugs was carried out in the present study.