Cytotoxicity of seputhecarpan D, thonningiol and 12 other phytochemicals from African flora towards human carcinoma cells

Kuete V., Ngnintedo D., Fotso G. W., KARAOSMANOĞLU O., Ngadjui B. T., Keumedjio F., ...More

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol.18, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18
  • Publication Date: 2018
  • Doi Number: 10.1186/s12906-018-2109-9
  • Journal Name: BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Africa, Carcinoma, Cytotoxicity, Mode of action, Seputhecarpan D, Thonningiol, RESISTANT CANCER-CELLS, NEBR. BRUMMITT LEGUMINOSAE, DIETARY TRITERPENE, INDUCED APOPTOSIS, BREAST-CANCER, LUPEOL, ISOFLAVONOIDS, MITOCHONDRIA, INHIBITION, FLAVONOIDS
  • Anadolu University Affiliated: Yes

Abstract

Background: Despite the remarkable progress in cancer therapy in recent years, this disease still remains a serious public health concern. The use of natural products has been and continues to be one of the most effective ways to fight malignancies. The cytotoxicity of 14 compounds from African medicinal plants was evaluated in four human carcinoma cell lines and normal fibroblasts. The tested samples included: beta-spinasterol (1), friedelanone (2), 16 beta-hydroxylupeol (3), beta-amyrin acetate (4), lupeol acetate (5), sequoyitol (6), rhamnitrin (7), europetin 3-O-rhamnoside (8), thonningiol (9), glyasperin F (10), seputhecarpan B (11), seputhecarpan C (12), seputhecarpan D (13) and rheediaxanthone A (14).