Iron removal from human plasma based on molecular recognition using imprinted beads

Yavuz H., Say R., Denizli A.

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, vol.25, no.4, pp.521-528, 2005 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 4
  • Publication Date: 2005
  • Doi Number: 10.1016/j.msec.2005.04.005
  • Journal Name: MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.521-528
  • Keywords: molecular imprinting, molecular recognition, iron removal, metal detoxification, affinity binding, SOLID-PHASE EXTRACTION, CADMIUM REMOVAL, POLYMERS, PRECONCENTRATION, SEPARATION, CHELATORS, COLUMN
  • Anadolu University Affiliated: No

Abstract

The aim of this study is to prepare ion-imprinted polymers which can be used for the selective removal of Fe3+ ions from Fe3+-overdosed human plasma. N-Methacryloly-(L)-glutamic acid (MAGA) was chosen as the complexing monomer. In the first step, Fe3+ was complexed with MAGA and the Fe3+-imprinted poly(HEMA-MAGA) beads were synthesized by suspension polymerization. After that, the template (i.e., Fe3+ ions) was removed using 0.1 M EDTA solution. The specific surface area of the Fe3+-imprinted poly(HEMA -MAGA) beads was found to be 76.4 in m(2)/g with a size range of 63-140 mu m in diameter and the swelling ratio was 75%. According to the elemental analysis results, the beads contained 84.7 mu mol MAGA/g polymer. The maximum adsorption capacity was 92.6 mu mol Fe3+/g beads. The relative selectivity coefficients of imprinted beads for Fe3+/Zn2+ and Fe3+/Cr3+ were 17.3 and 48.6 times greater than non-imprinted matrix, respectively. The Fe3+-imprinted poly(HEMA-MAGA) beads could be used many times without decreasing their adsorption capacities significantly. (c) 2005 Elsevier B.V. All rights reserved.