Composition, enantiomeric distribution, and antimicrobial activity of Tanacetum argenteum subsp flabellifolium essential oil

Tabanca N., DEMİRCİ F., Demirci B., Wedge D. E., BAŞER K. H. C.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol.45, no.5, pp.714-719, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 5
  • Publication Date: 2007
  • Doi Number: 10.1016/j.jpba.2007.08.006
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.714-719
  • Keywords: Tanacetum argenteum subsp.flabellifolium, Asteraceae, enantiomeric distribution, GC-MS, MDGC-MS, antimicrobial activity, SOLID-PHASE MICROEXTRACTION, SESQUITERPENE LACTONES, CHEMICAL-COMPOSITION, VULGARE L., EXTRACTION, PARTHENIUM, CANUM
  • Anadolu University Affiliated: Yes


Tanacetum argenteum (Lam.) Willd. subsp.flabellifolium, (Boiss. & Heldr.) Grierson of Asteraceae is an endemic species in Turkey. Hydrodistillation of aerial parts using a Clevenger apparatus yielded an essential oil, which was subsequently analyzed by gas chromatography-mass spectroscopy (GC-MS). alpha-Pinene (29%), (E)-sesquilavandulol (16%), and camphor (14%) were found as main constituents. Enantiomeric distribution of the monoterpenes a-pinene and camphor was determined on a fused silica Lipodex E capillary column using a multidimensional gas chromatography-mass spectroscopy (MDGC-MS) system, (-)-alpha-pinene (86%), (+)-a-pinene (14%), and (-)-camphor (100%) enantiomeric distributions were found in the oil. Furthermore, antimicrobial activity of the oil was carried out using a micro-dilution assay against human pathogenic bacteria and the yeast Candida albicans resulting in moderate inhibitory concentrations (MIC = 125 mu g/mL). (c) 2007 Elsevier B.V. All rights reserved.