Mirtazapine suppresses sterile inflammation through NLRP3-inflammasome in diabetic rat kidney

ŞAHİN, ERHAN; Bektur, Ezgi; BURUKOĞLU DÖNMEZ, DİLEK; Baycu, Cengiz; CAN, ÖZGÜR; ŞAHİNTÜRK, VAROL

doi:10.1016/j.acthis.2019.01.007

Mirtazapine suppresses sterile inflammation through NLRP3-inflammasome in diabetic rat kidney

ŞAHİN E., Bektur E., BURUKOĞLU DÖNMEZ D., Baycu C., CAN Ö. D., ŞAHİNTÜRK V.

ACTA HISTOCHEMICA, vol.121, no.3, pp.289-296, 2019 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 121 Issue: 3
Publication Date: 2019
Doi Number: 10.1016/j.acthis.2019.01.007
Journal Name: ACTA HISTOCHEMICA
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.289-296
Keywords: Diabetes mellitus, Kidney, Mirtazapine, NLRP3, Caspase-1, NLRP3 INFLAMMASOME, SIGNALING PATHWAYS, ACTIVATION, NEPHROPATHY, INTERLEUKIN-1-BETA, HIPPOCAMPUS, PROTEIN, CORTEX, DAMAGE, CELLS
Anadolu University Affiliated: Yes

Abstract

Aim The aim of this study was to investigate the effects of mirtazapine, which is anti-oxidative and antidepressant agent, on the kidney damage caused by diabetes mellitus.