BRADYKININ RECEPTORS IN INTESTINAL SMOOTH MUSCLES AND THEIR POSTRECEPTOR EVENTS RELATED TO CALCIUM

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ÖZTÜRK Y., ALTAN V., YILDIZOGLUARI N., ALTINKURT O.

MEDIATORS OF INFLAMMATION, cilt.2, sa.4, ss.309-315, 1993 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2 Sayı: 4
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1155/s0962935193000432
  • Dergi Adı: MEDIATORS OF INFLAMMATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.309-315
  • Anahtar Kelimeler: BRADYKININ, BRADYKININ RECEPTORS, CALCIUM, CALMODULIN, DES-ARG(9)-BRADYKININ, TRIFLUOPERAZINE, VERAPAMIL, RAT DUODENUM, PHOSPHODIESTERASE, ACTIVATOR, PROTEINS, BINDING, SITES
  • Anadolu Üniversitesi Adresli: Evet

Özet

THE effects of trifluoperazine and verapamil on bradykinin- and des-Arg9-bradykinin induced responses of isolated rat duodenum and guinea-pig ileum were investigated to elucidate post-bradykinin receptor events. Verapamil and trifluoperazine inhibited bradykinin induced relaxations and contractions and des-Arg9-bradykinin induced contractions in rat duodenum. Bradykinin induced contractions of ileum were also inhibited by trifluoperazine and verapamil. Since non-competitive affinity constants of trifluoperazine and verapamil for the relaxant responses to bradykinin in duodenum and for the contractile responses to bradykinin in ileum are different, post-bradykinin receptor events related to calcium may be different in ileum and duodenum. In addition, affinity constants of bradykinin in guinea-pig ileum and rat duodenum are also disparate suggesting the presence of different types of bradykinin B2 receptors in these two organs.