Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.23, no.24, pp.6764-6768, 2013 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 23 Issue: 24
- Publication Date: 2013
- Doi Number: 10.1016/j.bmcl.2013.10.024
- Journal Name: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
- Page Numbers: pp.6764-6768
- Keywords: Imidazole, Antimicrobial, Brine-Shrimp test, Anticancer, ANTIBACTERIAL, ANTITUMOR, RESISTANT
- Anadolu University Affiliated: Yes
Abstract
In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl)thio]-1-(aryl) ethanone derivatives were synthesized and investigated for their antibacterial, antifungal and anticancer activities. Toxicity of the most effective compounds was established by performing Brine-Shrimp lethality assay. Antifungal activity of the compounds was found to be higher than antibacterial and anticancer activities of the compounds. (C) 2013 Elsevier Ltd. All rights reserved.