Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives

YURTTAŞ L., DURAN M., DEMİRAYAK Ş., Gencer H. K., TUNALI Y.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.23, no.24, pp.6764-6768, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 24
  • Publication Date: 2013
  • Doi Number: 10.1016/j.bmcl.2013.10.024
  • Journal Name: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.6764-6768
  • Keywords: Imidazole, Antimicrobial, Brine-Shrimp test, Anticancer, ANTIBACTERIAL, ANTITUMOR, RESISTANT
  • Anadolu University Affiliated: Yes

Abstract

In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl)thio]-1-(aryl) ethanone derivatives were synthesized and investigated for their antibacterial, antifungal and anticancer activities. Toxicity of the most effective compounds was established by performing Brine-Shrimp lethality assay. Antifungal activity of the compounds was found to be higher than antibacterial and anticancer activities of the compounds. (C) 2013 Elsevier Ltd. All rights reserved.