Synthesis of some 2,4-di- and 2,3,4-trisubstituted benzimidazo[1,2-a]pyrimidines and evaluation of their cytotoxicities towards F2408 and 5RP7 cells

Meric A., Incesu Z., Karayel A., Ozbey S.

REVISTA DE CHIMIE, no.11, pp.1090-1097, 2006 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Publication Date: 2006
  • Journal Name: REVISTA DE CHIMIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.1090-1097
  • Keywords: fused azole heterocycles, benzimidazo[1,2-a]pyrimidine, cyclocondensation, crystal structure, cell culture, IN-VITRO, ANTIPROLIFERATIVE ACTIVITY, BIOLOGICAL IMPORTANCE, DERIVATIVES, BENZIMIDAZOLES, BINDING, AGENTS, 2-AMINOBENZIMIDAZOLES, HETEROCYCLES, SITE
  • Anadolu University Affiliated: Yes


This article describes the synthesis of 2,4-di- and 2,3,4-trisubstituted benzimidazo[1,2-alpyrimidine derivatives which were tested for their cytotoxicities and their spectral characterizations by IR, H-1- and C-13-NMR, El-MS. The fused title compounds were formed by the reaction of 2-aminobenzimidazole with beta-keto esters or 1,3-alkanediones in PhMe and MeOH or in PPA, respectively, by one-pot cyclocondensation reactions. Complete structural assignments of 2,4-di- and 2,3,4-trisubstituted benzimidazo[1,2-alpyrimidine derivatives were established by IR, H-1- and 13C-NMR and EI-MS spectroscopic investigations. Single-crystal diffraction analysis was performed for 6. The cytotoxicities of the synthesized compounds on the non-cancer cells (F2408) and cancer cells (5RP7) were evaluated.