Synthesis and Antifungal Activity Evaluation of New 1,2,4-Triazole Derivatives Bearing Salicylidene Hydrazide Moiety

DEMİRAYAK Ş., KAYAĞİL İ., YURTTAŞ L., Er S.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.13, sa.2, ss.178-184, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.2174/1570180812666150723001545
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.178-184
  • Anahtar Kelimeler: Salicylidene hydrazide, 1,2,4-triazole, antifungal activity, III SECRETION, HYDRAZONES, INHIBITORS, COMPLEXES, THIOSEMICARBAZONES, INFECTIONS, VIRULENCE, AGENTS
  • Anadolu Üniversitesi Adresli: Evet

Özet

A series of new N'-(arylidene)-2-[(1-(4-nitrophenyl)-1H-1,2,4-triazol-3-yl)oxy]acetohydrazide derivatives (116) were prepared and tested for theira ntifungal activity against six plant pathogens, three human pathogens and two non-pathogen microorganisms. The target compounds were obtained with a multi-step reaction starting from 4-substitutedarylhydrazine derivatives and the structures of final compounds have been elucidated with IR, NMR, Mass spectroscopy data and elemental analysis results. The antifungal activity of the compounds was determined against eleven different Fusarium, Trichoderma, Aspergillus and Penicilliumspeciesby using microdilution method. Most of the target compounds showed excellent antifungal activity against a variety of fungal pathogens.