N-Benzoylthiourea-pyrrolidine carboxylic acid derivatives bearing an imidazole moiety: Synthesis, characterization, crystal structure, in vitro ChEs inhibition, and antituberculosis, antibacterial, antifungal studies

POYRAZ, SAMET; DÖNDAŞ, HACI; Sansano, Jose; BELVEREN, SAMET; YAMALI, CEM; ÜLGER, MAHMUT; YAKTUBAY DÖNDAŞ, NACİYE; SAĞLIK, BEGÜM; Pask, Christopher

doi:10.1016/j.molstruc.2022.134303

N-Benzoylthiourea-pyrrolidine carboxylic acid derivatives bearing an imidazole moiety: Synthesis, characterization, crystal structure, in vitro ChEs inhibition, and antituberculosis, antibacterial, antifungal studies

Copy For Citation

POYRAZ S., DÖNDAŞ H. A., Sansano J. M., BELVEREN S., YAMALI C., ÜLGER M., ...More

JOURNAL OF MOLECULAR STRUCTURE, vol.1273, 2023 (SCI-Expanded)

Publication Type: Article / Article
Volume: 1273
Publication Date: 2023
Doi Number: 10.1016/j.molstruc.2022.134303
Journal Name: JOURNAL OF MOLECULAR STRUCTURE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, INSPEC
Anadolu University Affiliated: Yes

Abstract

A series of novel N -benzoylthiourea-pyrrolidine carboxylic acid derivatives bearing an imidazole moiety has been prepared and their various biological activities are evaluated. The ability of forming intermolecular hydrogen-bonds of these molecules was pursued in the search of the best antimicrobial activity. The synthesized compounds were tested to search whether they had an enzyme inhibitory potency against AChE and BChE, which are the main targets for Alzheimer's disease. The prepared compounds were also screened for antituberculosis activity against M. tuberculosis H37Rv strain and the antibacterial activity against E. coli, A. baumannii, S. aureus, B. subtilis, A. hydrophila, bacteria. In addition, their antifungal activities are also evaluated against C. tropicalis, C. albicans, C. glabrata strains. (c) 2022 Elsevier B.V. All rights reserved.