Synthesis of some 3-arylamino-5-aryloxymethyl[1,2,4]triazole derivatives and their antimicrobial activity

DEMİRAYAK Ş., BENKLİ K., Güven K.

Pharmaceutica Acta Helvetiae, vol.72, no.5, pp.285-290, 1998 (Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 72 Issue: 5
  • Publication Date: 1998
  • Doi Number: 10.1016/s0031-6865(97)00035-6
  • Journal Name: Pharmaceutica Acta Helvetiae
  • Journal Indexes: Scopus
  • Page Numbers: pp.285-290
  • Keywords: 3-Amino[1,2,4]triazole, Antimicrobial activity, Hydrazide, Thiourea
  • Anadolu University Affiliated: Yes

Abstract

In this study, some 3-arylamino-5-aryloxymethyl[1,2,4]triazole derivatives were synthesized by reacting S-methyl-N'-arylisothiouronium iodide and 2- (aryloxy)alkanoic acid hydrazide. The structural elucidation of the compounds was performed by IR, 1H-NMR and MS spectroscopic data and elemental analyses results. Antibacterial and antifungal activities of the compounds were examined.