Synthesis, Antibacterial, Antifungal, Antimycobacterial Activity Evaluation of Novel 1,2,4-triazole Derivatives Bearing 4-Aminophenyl Moiety

KAYA ÇAVUŞOĞLU B., YURTTAŞ L., YILMAZ CANKILIÇ M., KAPLANCIKLI Z. A.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.14, no.8, pp.938-948, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 8
  • Publication Date: 2017
  • Doi Number: 10.2174/1570180814666161130103624
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.938-948
  • Keywords: 1,2,4-Triazole, antibacterial, antifungal, antimycobacterial, tuberculosis (TB), multidrug resistant (MDR), ANTIMICROBIAL ACTIVITY, HIV, THIOSEMICARBAZIDES, TUBERCULOSIS, DESIGN, ASSAY
  • Anadolu University Affiliated: Yes

Abstract

Background: In this work, 2-[[5-(4-aminophenyl)-4-(4-substituted phenyl)-4H-1,2,4-triazol- 3-yl] thio]-1-(4-substituted phenyl) ethan-1-one derivatives (1-15) and 2-[[5-(4-aminophenyl)-4-( 4-substituted phenyl)-4H-1,2,4-triazol-3-yl] thio]-N-(4-substituted phenyl) acetamide derivatives (15-30) were synthesized using 4-aminobenzohydrazide as starting material.