New N'-Arylidene-2-[(4-Nitrophenyl) Piperazin-1-yl]Acetohydrazide Derivatives: Synthesis and Anticancer Activity Investigation

YURTTAŞ L., KAPLANCIKLI Z. A., Gorgulu-Kahyaoglu S.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.14, no.8, pp.910-917, 2017 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 14 Issue: 8
  • Publication Date: 2017
  • Doi Number: 10.2174/1570180814666161207163450
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.910-917
  • Keywords: Antiproliferative, apoptosis, cytotoxicity, hydrazone, piperazine, biological activities, PROCASPASE-ACTIVATING COMPOUND, ANNEXIN-V, BENZIMIDAZOLE DERIVATIVES, BIOLOGICAL EVALUATION, AGENTS
  • Anadolu University Affiliated: Yes

Abstract

Background: Compounds bearing ortho-hydroxy N-acyl hydrazone moiety have been reported with high anticancer activity acting by increasing the enzymatic activity of procaspase-3 in cancer cells and therefore inducing apoptosis in some tumour models.