New N'-Arylidene-2-[(4-Nitrophenyl) Piperazin-1-yl]Acetohydrazide Derivatives: Synthesis and Anticancer Activity Investigation

YURTTAŞ L., KAPLANCIKLI Z. A., Gorgulu-Kahyaoglu S.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.14, sa.8, ss.910-917, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 8
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2174/1570180814666161207163450
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.910-917
  • Anahtar Kelimeler: Antiproliferative, apoptosis, cytotoxicity, hydrazone, piperazine, biological activities, PROCASPASE-ACTIVATING COMPOUND, ANNEXIN-V, BENZIMIDAZOLE DERIVATIVES, BIOLOGICAL EVALUATION, AGENTS
  • Anadolu Üniversitesi Adresli: Evet

Özet

Background: Compounds bearing ortho-hydroxy N-acyl hydrazone moiety have been reported with high anticancer activity acting by increasing the enzymatic activity of procaspase-3 in cancer cells and therefore inducing apoptosis in some tumour models.