An Approach for Solubility Enhancement of Poorly Water-Soluble Drug Cefdinir with Polyvinyl Alcohol

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Namlı İ., Güleç K., Öztürk A. A.

8th International Drug Chemistry Conference, Antalya, Turkey, 27 February - 01 March 2020, pp.1-5, (Full Text)

  • Publication Type: Conference Paper / Full Text
  • City: Antalya
  • Country: Turkey
  • Page Numbers: pp.1-5
  • Anadolu University Affiliated: Yes

Abstract

Solid dispersions (SDs) prepared with water-soluble polymers have been successfully used to increase the solubility of many poorly water-soluble drugs. Although Cefdinir (CEF) is used in many microbial diseases, its bioavailability is quite low due to its low solubility in water. Therefore, CEF is a suitable candidate for the preparation of the SD. In this study, SDs were prepared with polyvinyl alcohol (PVA) to increase the solubility and bioavailability of CEF and SDs were characterized by analyzes such as solubility and in vitro dissolution studies.

Keywords: Cefdinir, Probe sonication, Polyvinyl alcohol, Solid dispersion