The effect of vasoactive intestinal peptide (VIP) and naloxone combination on survival rates in rats exposed to severe hemorrhage

Tikiz H., Tunçel N., Akin M. Z., Gürer F.

Peptides, vol.13, no.1, pp.83-89, 1992 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 1
  • Publication Date: 1992
  • Doi Number: 10.1016/0196-9781(92)90144-r
  • Journal Name: Peptides
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.83-89
  • Keywords: VASOACTIVE INTESTINAL PEPTIDE, SEVERE HEMORRHAGE, HISTAMINE, MAST CELL, NALOXONE, ANAPHYLACTIC SHOCK, POLYPEPTIDE, HYPOTENSION, MORPHINE
  • Anadolu University Affiliated: Yes

Abstract

In this experiment, the effects of different doses of vasoactive intestinal peptide (VIP) and naloxone (NLX) combinations on survival rates were investigated in rats exposed to 40% hemorrhage. A combination of 25 ng · kg-1 VIP + 5 mg · kg-1 NLX showed the best results on survival. The important prospect of this combination is to have the most potent inhibitory effect on mast cell degranulation. When this combination was given together with shed blood reperfusion and 7.5% NaCl, survival rate increased relative to the administration of shed blood alone and of 7.5% NaCl. These findings suggest that inhibition of mast cell degranulation has a beneficial effect on severe hemorrhage. © 1992.