Roeperone A, a new tetraoxygenated xanthone and other compounds from the leaves of Hypericum roeperianum Schimp. (Hypericaceae)

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Damen F., Simo Mpetga J. D., Demgne O. M. F., Celik I., Wamba B. E. N., Tapondjou L. A., ...Daha Fazla

NATURAL PRODUCT RESEARCH, cilt.36, sa.8, ss.2071-2077, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 8
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/14786419.2020.1845674
  • Dergi Adı: NATURAL PRODUCT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, CINAHL, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.2071-2077
  • Anahtar Kelimeler: Hypericum roeperianum, Hypericaceae, Xanthones, Antibacterial activity, XANTHONOLIGNOIDS, ANTIBACTERIAL, CONSTITUENTS, EXTRACTS
  • Anadolu Üniversitesi Adresli: Evet

Özet

Chemical investigation of the methanol extract from the leaves of H. roeperianum led to the isolation of a new tetraoxygenated xanthone along with eleven known compounds including six xanthones, one polyketide, one flavonoid, one ferulic acid derivative and two pentacyclic triterpenoids. Their structures were established on the basis of 1D- and 2D-NMR, UV, IR, and MS experiments, and by comparison of their spectroscopic data with those of similar compounds reported in the literature. The new xanthone was tested against a panel of eight bacterial strains including six Gram-negative and two Gram-positive bacteria. As results, it exhibited weak antibacterial activity with MIC values ranging from 64 to 128 mu g/mL.