Roeperone A, a new tetraoxygenated xanthone and other compounds from the leaves of Hypericum roeperianum Schimp. (Hypericaceae)

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Damen F., Simo Mpetga J. D., Demgne O. M. F., Celik I., Wamba B. E. N., Tapondjou L. A., ...More

NATURAL PRODUCT RESEARCH, vol.36, no.8, pp.2071-2077, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 8
  • Publication Date: 2022
  • Doi Number: 10.1080/14786419.2020.1845674
  • Journal Name: NATURAL PRODUCT RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, CINAHL, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.2071-2077
  • Keywords: Hypericum roeperianum, Hypericaceae, Xanthones, Antibacterial activity, XANTHONOLIGNOIDS, ANTIBACTERIAL, CONSTITUENTS, EXTRACTS
  • Anadolu University Affiliated: Yes

Abstract

Chemical investigation of the methanol extract from the leaves of H. roeperianum led to the isolation of a new tetraoxygenated xanthone along with eleven known compounds including six xanthones, one polyketide, one flavonoid, one ferulic acid derivative and two pentacyclic triterpenoids. Their structures were established on the basis of 1D- and 2D-NMR, UV, IR, and MS experiments, and by comparison of their spectroscopic data with those of similar compounds reported in the literature. The new xanthone was tested against a panel of eight bacterial strains including six Gram-negative and two Gram-positive bacteria. As results, it exhibited weak antibacterial activity with MIC values ranging from 64 to 128 mu g/mL.