Copy For Citation
Yenilmez E., Öztürk A. A., Başaran E.
LETTERS IN DRUG DESIGN AND DISCOVERY, vol.20, no.8, pp.1147-1157, 2023 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
20
Issue:
8
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Publication Date:
2023
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Doi Number:
10.2174/1570180820666230207122755
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Journal Name:
LETTERS IN DRUG DESIGN AND DISCOVERY
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE
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Page Numbers:
pp.1147-1157
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Anadolu University Affiliated:
Yes
Abstract
Background:
Rapidly dissolving oral strips have many advantages, especially in pediatric and
geriatric use. Benzydamine hydrochloride is an active substance with local analgesic, anesthetic, antimicrobial
and non-steroidal anti-inflammatory properties.
Objective:
The aim of the study was to formulate and characterize orally dispersible benzydamine hydrochloride-
loaded fast dissolving oral strips for the sufficient treatment of oral mucositis with high loading
capacity as well as high patient compliance considering ease of use.
Methods:
Oral strips were prepared by solvent casting method with many different polymer combinations
and evaluated for different characteristics. In vitro and ex vivo characterizations were performed.
Results:
In appearance oral strips were smooth and they were also uniform in thickness and weight. The
release rates of the active agent from oral strips reached 100% within 25 minutes. The disintegration time
was within the range of 15.5 ± 1.2 seconds. Due to ex vivo permeation studies steady-state flux of benzydamine
hydrochloride in simulated saliva and pH 6.8 were found to be 27.1 μg cm−2 h−1 ± 1.4 and 26.2 μg
cm−2 h−1 ± 1.7, respectively. No significant difference (p˃0.05) in permeability studies was observed using
pH 6.8 phosphate buffer compared to simulated saliva.
Conclusion:
Active agent was successfully loaded into the strips and the targeted system was successfully
performed. Benzydamine hydrochloride as oral strips can be a better solution for the efficient treatment of
oral mucositis for cancer patients during chemotherapy and radiotherapy stages.