Synthesis and cytotoxic and analgesic activities of some 1,5-diaryl-3-ethoxycarbonylpyrrole derivatives
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, sa.1, ss.113-118, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2006
- Doi Numarası: 10.1080/14756360500472845
- Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.113-118
- Anahtar Kelimeler: diarylpyrrole, cytotoxicity, analgesic activity, SELECTIVE CYCLOOXYGENASE-2 INHIBITORS, COX-2 INHIBITORS, BIOLOGICAL EVALUATION, 2,3-DIARYLTHIOPHENES, IDENTIFICATION, POTENT, SERIES
- Anadolu Üniversitesi Adresli: Evet
Özet
Some 1,5-diaryl-3-ethoxycarbonyl-2-methylpyrrole derivatives were obtained by reacting 1-aryl-3-ethoxycarbonylpent-1,4-diones and a suitable aniline derivative or sulfanilamide under Paal-Knorr pyrrole synthesis conditions. The cytotoxicity of the compounds was tested and all compounds, except for compound 2 h, showed a time-dependent increase in cytotoxic activity. Analgesic activities of the compounds were determined by using the tail-flick and tail-immersion methods; some of the compounds showed potent analgesic activity.