Design, Synthesis, In vitro and In silico Evaluation of New Hydrazone-based Antitumor Agents as Potent Akt Inhibitors

Gungor E. M., ALTINTOP M. D., SEVER B., AKALIN ÇİFTÇİ G.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.17, sa.11, ss.1380-1392, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 11
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1570180817999200618163507
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, EMBASE
  • Sayfa Sayıları: ss.1380-1392
  • Anahtar Kelimeler: Akt, apoptosis, cancer, hydrazone, molecular docking, pyrimidine, BIOLOGICAL EVALUATION, ANTICANCER, DERIVATIVES, APOPTOSIS, KINASE, SCAFFOLDS
  • Anadolu Üniversitesi Adresli: Evet

Özet

Background: Akt is overexpressed or activated in a variety of human cancers, including gliomas, lung, breast, ovarian, gastric and pancreatic carcinomas. Akt inhibition leads to the induction of apoptosis and inhibition of tumor growth and therefore extensive efforts have been devoted to the discovery of potent antitumor drugs targeting Akt.