Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives

Sahin Z., Ertas M., BERK B., Biltekin S. N., YURTTAŞ L., DEMİRAYAK Ş.

BIOORGANIC & MEDICINAL CHEMISTRY, cilt.26, sa.8, ss.1986-1995, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 8
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.bmc.2018.02.048
  • Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.1986-1995
  • Anahtar Kelimeler: Anticancer, Molecular modelling, Thiazoles, Aromatase, Non-steroidal, MOLECULAR DOCKING, BREAST-CANCER, MECHANISM, ANALOGS, DESIGN, PROLIFERATION, RESVERATROL
  • Anadolu Üniversitesi Adresli: Evet

Özet

Steroidal and non-steroidal aromatase inhibitors target the suppression of estrogen biosynthesis in the treatment of breast cancer. Researchers have increasingly focused on developing non-steroidal derivatives for their potential clinical use avoiding steroidal side-effects.