Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives

Sahin, Zafer; Ertas, Merve; BERK, BARKIN; Biltekin, Sevde; YURTTAŞ, LEYLA; DEMİRAYAK, ŞEREF

doi:10.1016/j.bmc.2018.02.048

Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives

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Sahin Z., Ertas M., BERK B., Biltekin S. N., YURTTAŞ L., DEMİRAYAK Ş.

BIOORGANIC & MEDICINAL CHEMISTRY, vol.26, no.8, pp.1986-1995, 2018 (SCI-Expanded)

Publication Type: Article / Article
Volume: 26 Issue: 8
Publication Date: 2018
Doi Number: 10.1016/j.bmc.2018.02.048
Journal Name: BIOORGANIC & MEDICINAL CHEMISTRY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
Page Numbers: pp.1986-1995
Keywords: Anticancer, Molecular modelling, Thiazoles, Aromatase, Non-steroidal, MOLECULAR DOCKING, BREAST-CANCER, MECHANISM, ANALOGS, DESIGN, PROLIFERATION, RESVERATROL
Anadolu University Affiliated: Yes

Abstract

Steroidal and non-steroidal aromatase inhibitors target the suppression of estrogen biosynthesis in the treatment of breast cancer. Researchers have increasingly focused on developing non-steroidal derivatives for their potential clinical use avoiding steroidal side-effects.