Synthesis and mutagenicity of 2-aryl-substitute (o-hydroxy-, m-bromo-, o-methoxy-, o-nitro-phenyl or 4-pyridyl) benzothiazole derivatives on Salmonella typhimurium and human lymphocytes exposed in vitro

Tuylu B. A., Zeytinoglu H. S., Isikdag I.

BIOLOGIA, cilt.62, sa.5, ss.626-632, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 5
  • Basım Tarihi: 2007
  • Doi Numarası: 10.2478/s11756-007-0122-4
  • Dergi Adı: BIOLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.626-632
  • Anahtar Kelimeler: 2-aryl-substitute benzothiazole, sister chromatid exchange, Ames test, ANTITUMOR BENZOTHIAZOLES, TUMOR-CELLS, POTENT, DISCOVERY, 2-(4-AMINOPHENYL)BENZOTHIAZOLES, BENZIMIDAZOLE, BENZOXAZOLE, AGENTS
  • Anadolu Üniversitesi Adresli: Evet

Özet

Derivatives of 2-aryl-substitute (o-hydroxy-, m-bromo-, o-methoxy-, o-nitro-phenyl or 4-pyridyl) benzothiazole were synthesized and tested for their mutagenicity in in vitro assays: (i) in the Ames test with Salmonella typhimurium TA98 and TA100 strains; and (ii) in the sister chromatid exchange (SCE) in cultured human lymphocytes. The four of compounds (BT-11, B-12, BT-14 and BT-15) caused statistically significant increase in revertant colonies of TA98 and TA100. Treatment of lymphocytes with compounds also caused a significant increase in SCE/cell in association with high levels and long exposure (300 mu g/mL and 48 h) of the four compounds. It can be concluded that benzothiazole derivatives showed mutagenic activity and were also able to exert a genotoxic effect reducing both the replication index and mitotic index.