Olopatadine hydrochloride loaded Kollidon (R) SR nanoparticles for ocular delivery: Nanosuspension formulation and in vitro-in vivo evaluation

GÜVEN U. M., Yenilmez E.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, cilt.51, ss.506-512, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.jddst.2019.03.016
  • Dergi Adı: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.506-512
  • Anahtar Kelimeler: Olopatadine hydrochloride, Nanoparticles, Ocular application, Drug delivery system, Sustained release, POLYMERIC NANOPARTICLES, DRUG-RELEASE, CHITOSAN NANOPARTICLES, CELLULAR UPTAKE, PART II, SYSTEMS, TEAR, EYE, FABRICATION, ADSORPTION
  • Anadolu Üniversitesi Adresli: Evet

Özet

Introduction: Allergic eye diseases includes a spectrum of diseases, with each state being characterized by a complicated immunopathology. In the present study, polymeric Kollidon (R) SR nanoparticles loaded with olopatadine hydrochloride (OLO) were formulated as a suspension for ocular drug delivery. The formulations were developed to treat ocular allergic disease and characterized by their improved duration of corneal retention.