Olopatadine hydrochloride loaded Kollidon (R) SR nanoparticles for ocular delivery: Nanosuspension formulation and in vitro-in vivo evaluation

GÜVEN U. M., Yenilmez E.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, vol.51, pp.506-512, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 51
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jddst.2019.03.016
  • Journal Name: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.506-512
  • Keywords: Olopatadine hydrochloride, Nanoparticles, Ocular application, Drug delivery system, Sustained release, POLYMERIC NANOPARTICLES, DRUG-RELEASE, CHITOSAN NANOPARTICLES, CELLULAR UPTAKE, PART II, SYSTEMS, TEAR, EYE, FABRICATION, ADSORPTION
  • Anadolu University Affiliated: Yes

Abstract

Introduction: Allergic eye diseases includes a spectrum of diseases, with each state being characterized by a complicated immunopathology. In the present study, polymeric Kollidon (R) SR nanoparticles loaded with olopatadine hydrochloride (OLO) were formulated as a suspension for ocular drug delivery. The formulations were developed to treat ocular allergic disease and characterized by their improved duration of corneal retention.