In vitro and in silico studies on AChE inhibitory effects of a series of donepezil-like arylidene indanones
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.45, sa.4, ss.359-363, 2020 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 45 Sayı: 4
- Basım Tarihi: 2020
- Doi Numarası: 10.1515/tjb-2019-0356
- Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.359-363
- Anahtar Kelimeler: Acetylcholinesterase, Alzheimer's disease, arylidene indanone, donepezil analogs, molecular docking, TARGETING ALZHEIMERS-DISEASE, MULTIFUNCTIONAL AGENTS, DRUG CANDIDATES, ACETYLCHOLINESTERASE, DERIVATIVES, DISCOVERY, CHALCONE, BEARING, DESIGN
- Anadolu Üniversitesi Adresli: Evet
Özet
Objective: Donepezil is the most potent acetylcholinesterase (AChE) inhibitor currently available on the market for the management of Alzheimer's disease. In this study, it was aimed to identify potent donepezil analogues.