A Comprehensive Study on Thiadiazole-Based Anticancer Agents Inducing Cell Cycle Arrest and Apoptosis/Necrosis Through Suppression of Akt Activity in Lung Adenocarcinoma and Glioma Cells

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AKALIN ÇİFTÇİ G., SEVER B., ALTINTOP M. D.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.16, no.2, pp.119-131, 2019 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.4274/tjps.galenos.2019.2018.96658
  • Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.119-131
  • Keywords: Apoptosis, Akt activity, cancer, molecular docking, thiadiazole, 1,3,4-THIADIAZOLE DERIVATIVES, BIOLOGICAL EVALUATION, INHIBITORS, KINASE, PROLIFERATION, DISCOVERY, SURVIVAL, PATHWAY
  • Anadolu University Affiliated: Yes

Abstract

Objectives: Akt is considered as an attractive target for anticancer drug discovery and development and therefore extensive efforts have been devoted to the discovery of new potent anticancer agents targeting Akt.