A Comprehensive Study on Thiadiazole-Based Anticancer Agents Inducing Cell Cycle Arrest and Apoptosis/Necrosis Through Suppression of Akt Activity in Lung Adenocarcinoma and Glioma Cells

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AKALIN ÇİFTÇİ G., SEVER B., ALTINTOP M. D.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.16, sa.2, ss.119-131, 2019 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.4274/tjps.galenos.2019.2018.96658
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.119-131
  • Anahtar Kelimeler: Apoptosis, Akt activity, cancer, molecular docking, thiadiazole, 1,3,4-THIADIAZOLE DERIVATIVES, BIOLOGICAL EVALUATION, INHIBITORS, KINASE, PROLIFERATION, DISCOVERY, SURVIVAL, PATHWAY
  • Anadolu Üniversitesi Adresli: Evet

Özet

Objectives: Akt is considered as an attractive target for anticancer drug discovery and development and therefore extensive efforts have been devoted to the discovery of new potent anticancer agents targeting Akt.