Formulation of microemulsions for dermal delivery of Cephalexin

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Üstündağ Okur N., ER S., Çağlar E. Ş., Ekmen T. Z., Sala F.

Acta Pharmaceutica Sciencia, vol.55, no.4, pp.27-40, 2017 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.23893/1307-2080.aps.05524
  • Journal Name: Acta Pharmaceutica Sciencia
  • Journal Indexes: Scopus
  • Page Numbers: pp.27-40
  • Keywords: Antibacterial activity, Cephalexin, Dermal delivery, In vitro release, Microemulsion
  • Anadolu University Affiliated: No


© 2017 University of Istanbul. All rights reserved.Introduction: Cephalexin monohydrate (CEM) is mostly used because of its activity against both the gram-positive and gram-negative microorganisms for infections. Microemulsions offer numerous advantages for dermal delivery of drugs. Objective: The objective of the present study was to prepare novel CEM loaded microemulsions and to characterize formulations, to evaluate their in vitro release profiles and antibacterial activities. Method: CEM loaded formulations [0.02% (w/w)] were characterized according to their droplet size, zeta potential, PDI, pH, electrical conductivity and viscosity. In addition, in vitro drug release studies and antibacterial activity tests were performed. Results: The developed CEM loaded microemulsions (M1 and M2) achieved narrow droplet size distribution (152.75±4.85 and 128.05±9.22), low PDI (0.364±0.05 and 0.489±0.06), suitable pH (5.28-4.84) and conductivity (342±4.472-374±5.477 µS/cm). Zeta potential was measured as 0.209±0.041 and 0.141±0.024 mV. M1CEM showed 100% release at the 7th hour and was provided almost the same zone diameter as CEM solution when evaluated for antibacterial activity. Conclusion: Overall, it was concluded that microemulsions might be beneficial in improving dermal delivery of CEM for the treatment of skin and soft tissue infections.