Essential Oil Composition, Antimicrobial and Cytotoxic Activities of Two Endemic Stachys cretica Subspecies (Lamiaceae) from Turkey

ŞERBETÇİ T., DEMİRCİ B., BOZKURT GÜZEL Ç., KÜLTÜR Ş., Erguven M., BAŞER K. H. C.

NATURAL PRODUCT COMMUNICATIONS, cilt.5, sa.9, ss.1369-1374, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 9
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1177/1934578x1000500907
  • Dergi Adı: NATURAL PRODUCT COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1369-1374
  • Anahtar Kelimeler: Stachys cretica ssp lesbiaca, Stachys cretica ssp trapezuntica, essential oil, antimicrobial, cytotoxicity, VOLATILE CONSTITUENTS, CHEMICAL-COMPOSITION, AERIAL PARTS, L., GLYCOSIDE
  • Anadolu Üniversitesi Adresli: Evet

Özet

The chemical compositions of the water-distilled essential oil of Stachys cretica ssp. lesbiaca Rech. fil. and S. cretica ssp. trapezuntica Rech. fil. were determined by GC and GC MS. Altogether 63 compounds were identified. The sesquiterpene hydrocarbon, germacrene D (20.3% and 12.9% respectively) was the main component identified in both oils. Furthermore, ethanol, light petroleum, dichloromethane, ethyl acetate and n-butanol extracts prepared from the aerial parts of the plants were tested for their antimicrobial activities against six bacterial strains and the yeast Candida albicans. The extracts exhibited no antibacterial activity, but the light petroleum and n-butanolic fractions showed low antifungal activities. Crude ethanolic extracts of the two subspecies were tested for their ability to inhibit the growth of HL-60 and Ishikawa human tumor cell lines. The IC50 values were 100 mu g/mL for the HL-60 cell line and 200 mu g/mL for the Ishikawa cell line.