Synthesis and Evaluation of a New Series of Thiazolyl-pyrazoline Derivatives as Cholinesterase Inhibitors

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TEMEL H. E., ALTINTOP M. D., ÖZDEMİR A.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.15, sa.3, ss.333-338, 2018 (ESCI, Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4274/tjps.20982
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.333-338
  • Anahtar Kelimeler: Benzodioxole, cholinesterases, Lipinski's rule of five, pyrazoline, thiazole, ALZHEIMERS-DISEASE, BIOLOGICAL EVALUATION, DRUG DISCOVERY, DUAL INHIBITORS, IDENTIFICATION, MANAGEMENT, TARGETS, BEARING
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Anadolu Üniversitesi Adresli: Evet

Özet

Objectives: In recent years, the design of anticholinesterase agents based on molecular hybridization of pharmacologically active scaffolds has attracted a great deal of interest in medicinal chemistry. For this purpose, we aimed to design and synthesize anticholinesterase agents based on the molecular hybridization of thiazole and pyrazoline scaffolds.