Synthesis and Evaluation of a New Series of Thiazolyl-pyrazoline Derivatives as Cholinesterase Inhibitors

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TEMEL H. E., ALTINTOP M. D., ÖZDEMİR A.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.15, no.3, pp.333-338, 2018 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.4274/tjps.20982
  • Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.333-338
  • Keywords: Benzodioxole, cholinesterases, Lipinski's rule of five, pyrazoline, thiazole, ALZHEIMERS-DISEASE, BIOLOGICAL EVALUATION, DRUG DISCOVERY, DUAL INHIBITORS, IDENTIFICATION, MANAGEMENT, TARGETS, BEARING
  • Anadolu University Affiliated: Yes

Abstract

Objectives: In recent years, the design of anticholinesterase agents based on molecular hybridization of pharmacologically active scaffolds has attracted a great deal of interest in medicinal chemistry. For this purpose, we aimed to design and synthesize anticholinesterase agents based on the molecular hybridization of thiazole and pyrazoline scaffolds.