Synthesis and biological evaluation of some new pyrimidine bearing 2,5-disubstituted 1,3,4-oxadiazole derivatives as cytotoxic agents

KAYA ÇAVUŞOĞLU B., KAPLANCIKLI Z. A., YURTTAŞ L., AKALIN ÇİFTÇİ G.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.42, no.2, pp.131-137, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1515/tjb-2016-0240
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.131-137
  • Keywords: 1,3,4-Oxadiazole, Pyrimidine, Cytotoxic activity, ANTIINFLAMMATORY ACTIVITY, ANTICANCER AGENTS, ACID, OXADIAZOLE, INHIBITION, ANALOGS, SERIES
  • Anadolu University Affiliated: Yes

Abstract

Objective: As a result of adverse effects including drug-resistance, toxicity and low bioavailability, there has been a crucial need for novel anticancer agents. In this present study, some novel 2,5-disubstituted 1,3,4-oxadiazole derivatives bearing pyridine moiety were synthesized and their potential cytotoxic activities were examined.