Synthesis and Biological Evaluation of New Quinoline-Based Thiazolyl Hydrazone Derivatives as Potent Antifungal and Anticancer Agents

Erguc A., ALTINTOP M. D., ATLI EKLİOĞLU Ö., SEVER B., İŞCAN G., Gormus G., ...More

LETTERS IN DRUG DESIGN & DISCOVERY, vol.15, no.2, pp.193-202, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.2174/1570180814666171003145227
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.193-202
  • Keywords: Thiazole, hydrazone, quinoline, anticancer activity, anticandidal activity, genotoxicity, IN-VITRO, CANCER-CELLS, LUNG-CANCER, ANTITUMOR-ACTIVITY, DRUG DISCOVERY, BREAST-CANCER, DESIGN, STEM, ANTIBACTERIAL, ISAVUCONAZOLE
  • Anadolu University Affiliated: Yes

Abstract

Background: In medicinal chemistry, thiazoles have gained great importance in anti-fungal and anticancer drug design and development. Objectives: The aim of this study was to synthesize new quinoline-based thiazolyl hydrazone derivatives and evaluate their anticandidal and anticancer effects.