Synthesis and Biological Evaluation of New Quinoline-Based Thiazolyl Hydrazone Derivatives as Potent Antifungal and Anticancer Agents
LETTERS IN DRUG DESIGN & DISCOVERY, vol.15, no.2, pp.193-202, 2018 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 15 Issue: 2
- Publication Date: 2018
- Doi Number: 10.2174/1570180814666171003145227
- Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.193-202
- Keywords: Thiazole, hydrazone, quinoline, anticancer activity, anticandidal activity, genotoxicity, IN-VITRO, CANCER-CELLS, LUNG-CANCER, ANTITUMOR-ACTIVITY, DRUG DISCOVERY, BREAST-CANCER, DESIGN, STEM, ANTIBACTERIAL, ISAVUCONAZOLE
- Anadolu University Affiliated: Yes
Abstract
Background: In medicinal chemistry, thiazoles have gained great importance in anti-fungal and anticancer drug design and development. Objectives: The aim of this study was to synthesize new quinoline-based thiazolyl hydrazone derivatives and evaluate their anticandidal and anticancer effects.