Synthesis and Biological Evaluation of New Quinoline-Based Thiazolyl Hydrazone Derivatives as Potent Antifungal and Anticancer Agents
LETTERS IN DRUG DESIGN & DISCOVERY, cilt.15, sa.2, ss.193-202, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 2
- Basım Tarihi: 2018
- Doi Numarası: 10.2174/1570180814666171003145227
- Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.193-202
- Anahtar Kelimeler: Thiazole, hydrazone, quinoline, anticancer activity, anticandidal activity, genotoxicity, IN-VITRO, CANCER-CELLS, LUNG-CANCER, ANTITUMOR-ACTIVITY, DRUG DISCOVERY, BREAST-CANCER, DESIGN, STEM, ANTIBACTERIAL, ISAVUCONAZOLE
- Anadolu Üniversitesi Adresli: Evet
Özet
Background: In medicinal chemistry, thiazoles have gained great importance in anti-fungal and anticancer drug design and development. Objectives: The aim of this study was to synthesize new quinoline-based thiazolyl hydrazone derivatives and evaluate their anticandidal and anticancer effects.