Effects of the vasoactive intestinal peptide on stress-induced mucosal ulcers and modulation of methylation of histamine in gastric tissue of the rats

Tunçel N., TUNÇEL M., Aboul-Enein H. Y.

Farmaco, vol.58, no.6, pp.449-454, 2003 (Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 6
  • Publication Date: 2003
  • Doi Number: 10.1016/s0014-827x(03)00060-0
  • Journal Name: Farmaco
  • Journal Indexes: Scopus
  • Page Numbers: pp.449-454
  • Keywords: Histamine, Stress, Stress-induced gastric ulcers, Vasoactive intestinal peptide
  • Anadolu University Affiliated: Yes


Vasoactive intestinal peptide (VIP) prevents stress-induced gastric ulcers, inhibits mast cell degranulation and protects gastric tissue from lipid peroxidation. Histamine has an important role in the development of gastric ulcers and mast cell derived histamine might be essential in this process. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.