Citalopram Induces Reproductive Toxicity in Male Rats


ILGIN S., AYDOĞAN KILIÇ G., BAYSAL M., KILIÇ V., KORKUT ÇELİKATEŞ B., Ucarcan S., ...Daha Fazla

BIRTH DEFECTS RESEARCH, cilt.109, sa.7, ss.475-485, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 109 Sayı: 7
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1002/bdr2.1010
  • Dergi Adı: BIRTH DEFECTS RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.475-485
  • Anahtar Kelimeler: citalopram, reproductive toxicity, oxidative stress, DNA damage, SPERM DNA-DAMAGE, FOLLICLE-STIMULATING-HORMONE, OXIDATIVE STRESS, SEMEN PARAMETERS, TESTICULAR TOXICITY, WISTAR RATS, ESCITALOPRAM, MORPHOLOGY, SEROTONIN, FSH
  • Anadolu Üniversitesi Adresli: Evet

Özet

Background: Citalopram hydrobromide (CTL) has been shown to cause sexual dysfunction; however, its reproductive toxicity potential has not been sufficiently elucidated in men. Therefore, we aimed to clarify the toxic effects of CTL on the reproductive system of male rats. Methods: For this purpose, CTL was administered at 5, 10, and 20 mg/kg/day to rats orally for 28 days. Sperm concentration, motility, and morphology were investigated using a computer-assisted sperm analysis system, and sperm DNA damage was detected using a Comet assay. The testes were histopathologically examined. Serum follicle-stimulating hormone, luteinizing hormone, and testosterone levels were measured and the oxidative status of testes was investigated. Results: Our results showed that sperm concentration was reduced, and abnormal sperm morphology and sperm DNA damage were increased in CTL-administered groups. Additionally, histopathological changes were observed in the testes of CTL-administered rats. Luteinizing hormone levels were increased in CTL-administered groups, while testosterone levels were increased in the 5 and 10 mg/kg CTL-administered groups. Decreased glutathione signaled enhanced oxidative stress in the 10 and 20 mg/kg CTL-administered groups. Conclusion: Thus, we concluded that CT induced testicular damage in male rats; this testicular damage was accompanied by oxidative stress and hormonal changes, which are considered as the important causes of reproductive disorders. (C) 2017 Wiley Periodicals, Inc.