Determination of Iloperidone in Pharmaceuticals by Validated High-Performance Liquid Chromatography
ANALYTICAL LETTERS, cilt.51, sa.1-2, ss.24-32, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 1-2
- Basım Tarihi: 2018
- Doi Numarası: 10.1080/00032719.2017.1302462
- Dergi Adı: ANALYTICAL LETTERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.24-32
- Anahtar Kelimeler: High-performance liquid chromatography (HPLC), iloperidone, pharmaceuticals, tablets, TANDEM MASS-SPECTROMETRY, HUMAN PLASMA, METABOLITES, QUANTIFICATION, ANTIPSYCHOTICS, SERUM
- Anadolu Üniversitesi Adresli: Evet
Özet
Iloperidone is an antipsychotic drug used for treatment of acute schizophrenia in adults. In this study, a simple and specific method was developed for determination of iloperidone in tablets. The separation was performed on a C18 column using pH 3 20 mM phosphate buffer and acetonitrile as the mobile phase. The optimum conditions were 1 ml/min flow rate, 35 degrees C column temperature, and 2 mu L injection volume. Carbamazepine was used as an internal standard. Iloperidone was monitored at 274 nm with a diode array detector. The method was validated according to the literature guidelines and was linear from 0.5 to 100 mu g/ml of iloperidone. The detection and quantification limits were 0.0909 and 0.3030 mu g/ml, respectively. The method was acceptable in terms of accuracy, precision, specificity, robustness, and stability and employed for the analysis of tablets.