NO levels in diabetes mellitus: Effects of L-NAME and insulin on LCAT, Na+/K+ ATPase activity and lipid profile

Tekin N., Akyuz F., TEMEL H. E.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS, vol.5, no.4, pp.191-195, 2011 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.1016/j.dsx.2010.12.004
  • Journal Name: DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.191-195
  • Keywords: Diabetes, Nitric oxide, Na+/K+ ATPase, LCAT, L-NAME, NITRIC-OXIDE, DENSITY-LIPOPROTEIN, OXIDATIVE STRESS, STREPTOZOTOCIN, RATS, ERYTHROCYTE, INHIBITION, METABOLISM, SERUM
  • Anadolu University Affiliated: Yes

Abstract

Objectives: Diabetes mellitus (DM) is a chronic disease and one of the most important health problems. Several factors may be responsible for the complications of diabetes mellitus including alterations in the activities of sodium-potassium adenosine triphosphatase (Na+/K+ ATPase) and lecithin: cholesterol acyltransferase (LCAT) and also levels of nitric oxide (NO). We have investigated the effects of alterations in serum NO levels on activities of erythrocyte membran Na/K ATPase and serum LCAT enzymes.