Synthesis, X-ray characterization and evaluation of potent anti-angiogenic activity of a novel copper(II)-imidazole-bipyridyl complex

Unver H., DİKMEN G., KIYAN H. T.

INORGANIC AND NANO-METAL CHEMISTRY, cilt.52, sa.8, ss.1153-1160, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 8
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/24701556.2021.1963279
  • Dergi Adı: INORGANIC AND NANO-METAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1153-1160
  • Anahtar Kelimeler: Copper, imidazole, anti-angiogenic, in vivo CAM assay, EMBRYO CHORIOALLANTOIC MEMBRANE, ANTICANCER ACTIVITY, COPPER-COMPLEXES, IN-VITRO, ANTIANGIOGENIC ACTIVITY, METAL-COMPLEXES, DNA-BINDING, NI(II), CO(II), VIVO
  • Anadolu Üniversitesi Adresli: Evet

Özet

In this study, 1-(4-(trifluoromethyl)benzyl)-1H-imidazole, (ImCF(3)) and 2,2 '-bipyridyl, (bipy) ligands coordinating copper(II) complex have been synthesized and successfully characterized by single crystal X-ray diffraction, FT-IR and UV-vis and elemental analysis techniques. The agreement between experimental and theoretical results have been observed. Information about local and global chemical activity, electrophilic and nucleophilic nature of copper(II) complex have been theoretically obtained. The anti-angiogenic activity results indicated that copper(II) complex showed significantly very strong anti-angiogenic potential with higher anti-angiogenic score (average score = 1.06 +/- 0.01) than the standard anti-angiogenic (+/-)-Thalidomide (average score = 0.8 +/- 0.2) with no irritation and embryotoxicity whereas both ligands of the complex showed weak anti-angiogenic effects and one of the ligands ImCF(3) showed significant and higher irritation potential (86 +/- 20%) when compared with the standard irritant agent SDS (84 +/- 10%) on the CAM at 50 mu g/pellet.