A New Series of Antileukemic Agents: Design, Synthesis, In Vitro and In Silico Evaluation of Thiazole-Based ABL1 Kinase Inhibitors

Zeytun E., ALTINTOP M. D., SEVER B., ÖZDEMİR A., Ellakwa D. E., Ocak Z., ...More

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.21, no.9, pp.1099-1109, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 9
  • Publication Date: 2021
  • Doi Number: 10.2174/1871520620666200824100408
  • Journal Name: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.1099-1109
  • Keywords: Thiazole, ABL1 kinase, apoptosis, chronic myeloid leukemia, molecular docking, antileukemic agents
  • Anadolu University Affiliated: Yes

Abstract

Background: After the approval of imatinib, more than 25 antitumor agents targeting kinases have been approved, and several promising candidates are at various stages of clinical evaluation.