A New Series of Antileukemic Agents: Design, Synthesis, In Vitro and In Silico Evaluation of Thiazole-Based ABL1 Kinase Inhibitors

Zeytun E., ALTINTOP M. D., SEVER B., ÖZDEMİR A., Ellakwa D. E., Ocak Z., ...Daha Fazla

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.21, sa.9, ss.1099-1109, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 9
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2174/1871520620666200824100408
  • Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1099-1109
  • Anahtar Kelimeler: Thiazole, ABL1 kinase, apoptosis, chronic myeloid leukemia, molecular docking, antileukemic agents
  • Anadolu Üniversitesi Adresli: Evet

Özet

Background: After the approval of imatinib, more than 25 antitumor agents targeting kinases have been approved, and several promising candidates are at various stages of clinical evaluation.