3,4,5-Trisubstituted-1,2,4-triazole Derivatives as Antiproliferative Agents: Synthesis, In vitro Evaluation and Molecular Modelling

YURTTAŞ L., Evren A. E., Kubilay A., TEMEL H. E., AKALIN ÇİFTÇİ G.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.17, sa.12, ss.1502-1515, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 12
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1570180817999200712190831
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, EMBASE
  • Sayfa Sayıları: ss.1502-1515
  • Anahtar Kelimeler: Triazole, thiazole, apoptosis, MMP-9, caspase-3, A549, molecular modelling, BIOLOGICAL EVALUATION, ANTICANCER EVALUATION, CANCER-CELLS, APOPTOSIS, INHIBITORS, THIAZOLE, INDUCERS, DOCKING, HYBRIDS, DESIGN
  • Anadolu Üniversitesi Adresli: Evet

Özet

Background: Cancer is the name given to various diseases that are mainly uncontrolled, related to cell growth and can affect various organs. Among them, lung cancer is the one, which, in its earliest stages, is difficult to diagnose, and it is asymptomatic until the disease progresses. Triazole ring is an important heterocyclic ring known with various pharmacological activities.