Preparation of Some Thiazolyl Hydrazone Derivatives and Evaluation of Their Antibacterial Activities

Turan-Zitouni G., ÖZDEMİR A., KAPLANCIKLI Z. A., Fehrentz J., Martinez J., Chevallet P., ...Daha Fazla

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, cilt.184, sa.10, ss.2613-2623, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 184 Sayı: 10
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1080/10426500802534176
  • Dergi Adı: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.2613-2623
  • Anahtar Kelimeler: Amino acid, antibacterial activity, thiazole, BACTERIAL PROTEIN-SYNTHESIS, INHIBITOR, BIOSYNTHESIS, THIOSTREPTON, ANTIBIOTICS, BINDING
  • Anadolu Üniversitesi Adresli: Evet

Özet

The increasing clinical importance of drug-resistant fungal and bacterial pathogens has provided additional urgency to microbiological research and to the development of new antibacterial compounds. For this purpose, new tert-butyl [1-aryl/alkyl-2[(4-aryl-2-thiazolyl)hydrazono]ethyl]carbamate derivatives were synthesized and evaluated for antibacterial activity. The reaction of Boc-L-phenylalaninal, Boc-D-phenylalaninal, Boc-L-leucinal, and Boc-L-tryptophanal with thiosemicarbazide yielded the thiosemicarbazones, which furnished the title compounds on reaction with phenacyl bromides. The new compounds were screened for antibacterial activity. The results from the bioassay tests show that some of the compounds have notable activity against Gram-positive bacteria.