Preparation of Some Thiazolyl Hydrazone Derivatives and Evaluation of Their Antibacterial Activities

Turan-Zitouni G., ÖZDEMİR A., KAPLANCIKLI Z. A., Fehrentz J., Martinez J., Chevallet P., ...More

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, vol.184, no.10, pp.2613-2623, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 184 Issue: 10
  • Publication Date: 2009
  • Doi Number: 10.1080/10426500802534176
  • Journal Name: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.2613-2623
  • Keywords: Amino acid, antibacterial activity, thiazole, BACTERIAL PROTEIN-SYNTHESIS, INHIBITOR, BIOSYNTHESIS, THIOSTREPTON, ANTIBIOTICS, BINDING
  • Anadolu University Affiliated: Yes

Abstract

The increasing clinical importance of drug-resistant fungal and bacterial pathogens has provided additional urgency to microbiological research and to the development of new antibacterial compounds. For this purpose, new tert-butyl [1-aryl/alkyl-2[(4-aryl-2-thiazolyl)hydrazono]ethyl]carbamate derivatives were synthesized and evaluated for antibacterial activity. The reaction of Boc-L-phenylalaninal, Boc-D-phenylalaninal, Boc-L-leucinal, and Boc-L-tryptophanal with thiosemicarbazide yielded the thiosemicarbazones, which furnished the title compounds on reaction with phenacyl bromides. The new compounds were screened for antibacterial activity. The results from the bioassay tests show that some of the compounds have notable activity against Gram-positive bacteria.