Simultaneous Determination of Substance P and CGRP in Rat Brainstem Tissue Using LC-ESI-MS/MS Method

Alasag N., ŞENER E., Dogrukol-Ak D.

CURRENT ANALYTICAL CHEMISTRY, vol.14, no.6, pp.583-590, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.2174/1573411014666180111150237
  • Journal Name: CURRENT ANALYTICAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.583-590
  • Keywords: Substance P, CGRP, LC-ESI-MS/MS, rat brainstem tissue, neuropeptide, determination, GENE-RELATED PEPTIDE, MASS-SPECTROMETRY, PROSTAGLANDIN E-2, SPINAL-CORD, NEUROPEPTIDES, MIGRAINE, RELEASE, QUANTIFICATION, ELECTROPHORESIS, INHIBITION
  • Anadolu University Affiliated: Yes

Abstract

Background: Substance P and CGRP are neuropeptides that belong to the thachykinin and calcitonin family, respectively. They play an important role in neuropathic pain development and regulation.