Voltammetric and amperometric determination of metoclopramide on boron-doped diamond film electrode

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Dejmkova H., Dag C., Barek J., Zima J.

CENTRAL EUROPEAN JOURNAL OF CHEMISTRY, vol.10, no.4, pp.1310-1317, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.2478/s11532-012-0056-8
  • Journal Name: CENTRAL EUROPEAN JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1310-1317
  • Keywords: Metoclopramide, Differential pulse voltammetry, Flow injection analysis, Boron-doped diamond film electrode, Passivation, GLASSY-CARBON ELECTRODE, INJECTION SPECTROPHOTOMETRIC DETERMINATION, PERFORMANCE LIQUID-CHROMATOGRAPHY, TANDEM MASS-SPECTROMETRY, ELECTROCHEMICAL DETECTION, PASTE ELECTRODE, POTENTIOMETRIC DETERMINATION, PHARMACEUTICAL FORMULATIONS, MEMBRANE SENSOR, HUMAN PLASMA
  • Anadolu University Affiliated: Yes

Abstract

New methods for the determination of metoclopramide, antiemetic and gastroprokinetic pharmaceutical, were developed, using differential pulse voltammetry (DPV) and flow injection analysis (FIA) with amperometric detection on a boron-doped diamond film electrode. Electrode pretreatment necessary to ensure the stable results was investigated and it was found, that while DPV requires frequent electrode cleaning, FIA with a sufficiently high flow rate can maintain a stable signal with no signs of electrode passivation. The calculated quantification limits of the DPV and FIA with amperometric detection were 0.13 mu mol L-1 and 0.015 mmol L-1, respectively. The applicability of the new methods was verified by the determination of metoclopramide in a pharmaceutical preparation. FIA with amperometic detection proved to be sensitive, accurate and, due to the resistance of the electrode to the passivation, also simple to handle.